Database : HANSEN Search on : RELACAO DOSE-RESPOSTA IMUNOLOGICA [Subject descriptor] References found : 10 [refine] Displaying: 1 .. 10   in format [Detailed]

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Id: 13474 Author: Shepard, Charles C; Van Landingham, Rosalind M; Walker, Laura L; Ye, Shang-Zhang Title: Comparison of the immunogenicity of vaccines prepared from viable Mycobacterium bovis BCG, heat-killed Mycobacterium leprae, and a mixture of the two for normal and M. leprae-tolerant mice ..- Source: s.l; s.n; jun. 1983. 8 p. graf. Abstract: Intradermal vaccines consisting of viable Mycobacterium bovis BCG, heat-killed Mycobacterium leprae, or mixtures of the two were titrated in mice in doses of 10(5.2), 10(5.8), 10(6.4), 10(7.0), and 10(7.6) acid-fast bacilli. The immune response was measured by sensitization (48 to 72 h foot pad enlargement on challenge with 10(7.0) heat-killed M. leprae) and by protection against infection with a viable M. leprae challenge. There was increasing response with increasing dose of vaccine, and overall the responses to the three vaccines were similar. At the lowest dose, however, the combination of BCG and M. leprae gave superior protection. The local reaction to the vaccines in the lower dose range was less severe with the M. leprae vaccine. In another experiment, the three vaccines were compared in normal mice and in mice that had been rendered tolerant by intravenous injection of M. leprae. The tolerant mice developed no measurable sensitization on vaccination with M. leprae, but they developed partial but distinct sensitization on vaccination with BCG, alone or in combination with M. leprae. The tolerant mice developed little or no protection with any of the vaccines, however..(AU). Descriptors: MYCOBACTERIUM LEPRAE/imunol HANSENIASE/imunol TOLERÂNCIA IMUNOLOGICA VACINACAO RELACAO DOSE-RESPOSTA IMUNOLOGICA VACINAS BACTERIANAS/imunol VACINA BCG/imunol Limits: ESTUDO COMPARATIVO ANIMAL FEMININO CAMUNDONGOS SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 01555/s

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Id: 13472 Author: Smelt, A. H; Liew, F. Y; Rees, R. J Title: Lymphocyte response of leprosy patients to human-derived and purified armadillo-derived Mycobacterium leprae, BCG and PPD ..- Source: s.l; s.n; nov. 1978. 6 p. graf. Abstract: The lymphocyte transformation test was applied to compare in vitro lymphocyte responses of tuberculoid (high resistant) and lepromatous (low resistant) leprosy patients to purified Mycobacterium leprae derived from experimentally infected armadillos and crude M. leprae derived from man, as well as to bacille Calmette-Guérin (BCG) and purified protein derivative (PPD). It was found that the purification procedure using enzymic digestion did not affect the immunogenicity of armadillo-derived M. leprae as compared with the crude human-derived preparation, although 2.5-5-fold higher doses of the purified organisms were required to elicitate equivalent lymphocyte responses. The result indicated the suitability of purified armadillo-derived M. leprae as the standard antigen for lymphocytes transformation tests in leprosy. The cross-reactivity studies show a close relationship between PPD and BCG, but not between M. leprae and PPD or BCG.(AU). Descriptors: TRANSFORMACAO LINFOCITICA HANSENIASE/imunol MYCOBACTERIUM BOVIS/imunol TUBERCULINA/imunol RELACAO DOSE-RESPOSTA IMUNOLOGICA TATUS/imunol VACINA BCG MYCOBACTERIUM LEPRAE/imunol Limits: HUMANO ANIMAL ADULTO MEIA-IDADE ADOLESCENTE Electronic Medium: http://www.ilsl.br Location: BR191.1; 01550/s

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Id: 13416 Author: Bjune, G Title: In vitro lymphocyte stimulation in leprosy; simultaneous stimulation with Mycobacterium leprae antigens and phytohaemagglutinin ..- Source: s.l; s.n; jun. 1979. 9 p. tab, graf. Abstract: Peripheral blood lymphocytes from 105 subjects with different forms of leprosy and healthy contacts of leprosy patients weere stimulated in vitro different preparations of mycobacterial antugens alone or in combination with a suboptimal dose of phytohaemagglutinin (PHA). In nearly all individuals sonicated leprosy bacilli and PHA together gave a lower 3H-thymidine incorporation than didi the same dose of PHA alone. There was no difference in the degree of inhibition seen in the different patient groups or the healthy contacts. High doses of whole, washed Mycobacterium leprae, combined with PHA led to an increased thymidine incorporation in borderline tuberculoid leprosy patients who had experienced a reversal reaction, and in healthy contacts with less than 6 months exposure did not show an augmentation of the PHA-induced thymidine incorporation. The inhibition exerted by sonicated M. leprae was dose-dependent, seen even with very low doses of antigen, and was not due to direct Cytotoxicity, M. bovis, strain BCG, was weakly suppressive effect. There was no correlation between the suppressive effective of M. leprae antigens and the other mtcobacteria neither was there any correlation with the responses to the mycobacterial antigens alone. Many lepromatous leprosy patients showed significant suppression of background incorporation with addition of M. leprae antigens. This paper discusses wheter the apparent `non-responsiveness` in lepromatous leprosy could be due to active suppressor mechanisms operative in vitro.(AU). Descriptors: ANTIGENOS DE BACTERIAS/imunol ANTIGENOS DE SUPERFÍCIE/imunol HANSENIASE/imunol HANSENIASE/metab TRANSFORMACAO LINFOCITICA TIMIDINA/metab FITOHEMAGLUTININAS/farmacol MYCOBACTERIUM LEPRAE/imunol RELACAO DOSE-RESPOSTA IMUNOLOGICA LINFOCITOS/metab Limits: HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 00020/s

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Id: 13218 Author: Mehra, Vijay; Bloom, Barry R Title: Induction of cell-mediated immunity to Mycobacterium leprae in guinea pigs ..- Source: s.l; s.n; mar. 1979. 8 p. ilus, tab. Abstract: Guinea pigs immunized with intact or disrupted armadillo-grown human Mycobacterium leprae administered in aqueous or oil vehicles were tested with various dilutions of M. leprae suspended in saline, water-soluble M. leprae extract, purified protein derivative, and a water-soluble extract of normal armadillo tissue. The results demonstrated the following. (i) Under no conditions was any skin test reactivity found to normal armadillo tissue extract. (ii) Positive sensitization to both M. leprae and its water-soluble extract was achieved by sensitizing guinea pigs with M. leprae suspended in Hanks solution or saline. Autoclaved M. leprae in Hanks solution or saline inoculated intradermally was an effective immunogen. Oil suspensions or emulsions were effective at sensitization, but appeared to be no better and, in general, slightly weaker, than simple inoculation in aqueous suspension. (iii) Living BCG failed to reveal a significant adjuvant effect on sensitization to M. leprae. However, cord factor appeared to potentiate slightly the sensitization to M. leprae in aqueous suspension. (iv) The minimum dose required for sensitization with M. leprae in aqueous suspension was 55 micrograms of purified bacilli. (v) Animals inoculated with M. leprae in saline or with M. leprae together with BCG showed positive skin test reactivity to the first skin test application made fully 1 year after the initial sensitization. The efficacy of autoclaved, irradiated M. leprae in aqueous, oil-free medium suggests a relatively safe approach to human vaccination studies.(AU). Descriptors: HANSENIASE/imunol MYCOBACTERIUM BOVIS/imunol MYCOBACTERIUM LEPRAE/imunol TESTES CUTÂNEOS REACOES CRUZADAS RELACAO DOSE-RESPOSTA IMUNOLOGICA HIPERSENSIBILIDADE TARDIA/imunol IMUNIDADE CELULAR VACINA BCG Limits: ANIMAL COBAIAS TATUS Electronic Medium: http://www.ilsl.br Location: BR191.1; 02201/s

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Id: 12308 Author: Blatt, Jucelene Marchi Title: Considerações acerca dos estados reacionais do portador de hanseníase no município de Itajaí Considerations on reactional states of Itajai's hansen's carriers- Source: s.l; s.n; 2001. 10 p. tab. Descriptors: HANSENIASE PROGRAMAS MÉDICOS REGIONAIS AVALIAÇAO DE PROCESSOS E RESULTADOS (CUIDADOS DE SAUDE) RESULTADO DE TRATAMENTO REGISTROS MÉDICOS MYCOBACTERIUM LEPRAE TALIDOMIDA CLOFAZIMINA RIFAMPINA DAPSONA ANTICORPOS ANTIBACTÉRIAS RELAÇAO DOSE-RESPOSTA IMUNOLOGICA Location: BR191.1; 08738/s

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Id: 11430 Author: Blatt, Jucelene Marchi Title: Considerações acerca dos estados reacionais do portador de hanseníase no Município de Itajaí Considerations on reactional states of Itajai's hansen's carriers- Source: s.l; s.n; 2001. 10 p. tab. Descriptors: HANSENIASE PROGRAMAS MÉDICOS REGIONAIS AVALIAÇAO DE PROCESSOS E RESULTADOS (CUIDADOS DE SAUDE) RESULTADO DE TRATAMENTO REGISTROS MÉDICOS MYCOBACTERIUM LEPRAE TALIDOMIDA RIFAMPINA DAPSONA ANTICORPOS ANTIBACTÉRIAS RELAÇAO DOSE-RESPOSTA IMUNOLOGICA CRIANÇA Location: BR191.1; 08312/s

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Id: 9406 Author: Mullins, Raymond J; Roche, Paul; Adams, Elizabeth; Jones, Phillip; Chen, Sharon; Theuvenet, Win; Basten, Antony Title: Limiting dilution analysis in leprosy ..- Source: s.l; s.n; 1992. 14 p. ilus, tab, graf. Descriptors: ANTIGENOS DE BACTÉRIAS RELAÇAO DOSE-RESPOSTA IMUNOLOGICA RECEPTORES DA INTERLEUCINA 2 HANSENIASE MYCOBACTERIUM BOVIS MYCOBACTERIUM LEPRAE LINFOCITOS Location: BR191.1; 06396/s

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Id: 9324 Author: Bretscher, Peter A Title: A strategy to improved the efficacy of vaccination against tuberculosis and leprosy ..- Source: s.l; s.n; 1992. 4 p. . Descriptors: VACINA BCG VACINA BCG VACINAS BACTERIANAS VACINAS BACTERIANAS SUSCETIBILIDADE A DOENÇA SUSCETIBILIDADE A DOENÇA RELAÇAO DOSE-RESPOSTA IMUNOLOGICA HIPERSENSIBILIDADE TARDIA IMUNIDADE CELULAR LEISHMANIA TROPICA LEISHMANIOSE CUTANEA LEISHMANIOSE CUTANEA HANSENIASE HANSENIASE HANSENIASE CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS BALB C CAMUNDONGOS ENDOGAMICOS BALB C MYCOBACTERIUM BOVIS MYCOBACTERIUM BOVIS MYCOBACTERIUM LEPRAE MYCOBACTERIUM TUBERCULOSIS RATOS TUBERCULOSE TUBERCULOSE TUBERCULOSE VACINAÇAO Limits: ANIMAL Location: BR191.1; 06477/s

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Id: 8371 Author: Barnass, S; Mace, J; Steele, J; Torres, P; Gervasoni, B; Ravioli, R; Terencio, J; Rook, G. A. W; Waters, M. F. R Title: Prevalence and specificity of the enhancing effect of three types of interleukin 2 on T cell responsiveness in 97 lepromatous leprosy patients of mixed athnic origin ..- Source: s.l; s.n; 1986. 9 p. tab. Descriptors: ANTIGENOS DE BACTÉRIAS RELAÇAO DOSE-RESPOSTA IMUNOLOGICA HANSENIASE TRANSFORMAÇAO LINFOCITICA MYCOBACTERIUM LEPRAE MYCOBACTERIUM TUBERCULOSIS LINFOCITOS T TIMIDINA Location: BR191.1; 02412/s

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Id: 3596 Author: Hoffenbach, Agnès; Bach, Marie-Anne Title: Bacillary growth, interleukin 2 production defect, and specific antibody secretion governed by different genetical factors in mice infected subcutaneously with Mycobacterium lepraemurium ..- Source: s.l; s.n; 1986. 14 p. tab, graf. Descriptors: HANSENIASE MYCOBACTERIUM LEPRAEMURIUM ANTICORPOS ANTIBACTÉRIAS ESPECIFICIDADE DE ANTICORPOS RELAÇAO DOSE-RESPOSTA IMUNOLOGICA IGG RECEPTORES DA INTERLEUCINA 2 CAMUNDONGOS CAMUNDONGOS DE CEPAS ENDOGAMICAS LINFOCITOS T Location: BR191.1; 02434/s

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